Staff Scientist – Sickle Cell Anemia
Acetylon Pharmaceuticals Inc. is a Boston-area company, recently formed to commercialize innovative drug discovery technology emerging from collaborative research at Harvard University and the Dana-Farber Cancer Institute. Acetylon is pursuing the clinical development and commercialization of the next generation, selective, small-molecule Histone Deacetylase (HDAC) inhibitors with enhanced therapeutic effectiveness and improved safety profiles. The company recently completed a $27+M Series B financing and is located in the South Boston Seaport area.
We are seeking highly talented, motivated and energetic team member to join us to pursue an exciting opportunity to discover epigenetic modulating drugs for the treatment of sickle cell anemia, beta thalassemia and other epigenetic-based disorders.
Title: Scientist/Staff Scientist
Responsibilities:
- Independently design, carry out and analyze cell-based assays for changes in chromatin modification, gene expression and cell marker expression in hematopoetic stem cells and other cell types
- Work closely with outside contract research and academic labs to design and execute animal models
- Analyze, interpret and present results using standard software and spreadsheets (Prism, Excel, PowerPoint, etc.)
- Evaluate and initiate new drug discovery projects aligned with the commercial and scientific interests of Acetylon
- Present results at scientific meetings and establish contacts with leading researchers in the field of genetic diseases, particularly sickle cell anemia and beta thalassemia
Background:
- PhD in Biochemistry, Cell Biology, Molecular Biology or other related area
- 5+ years experience in biopharma or academic lab
- Strong background in characterization of gene expression and chromatin modification in cell lines and primary cells especially hematological cell types
- Experience working in the areas of hemoglobinopathies such as sickle cell anemia, beta thalassemia or other genetic disorders a plus
- Strong background in the biochemistry and biology of histone deacetylases, histone acetyltransferases and other epigenetic modification pathway members is desirable
- Drug discovery experience is a plus, especially in the area of epigenetic targets
- Can function with minimal supervisory guidance in a fast-paced environment
To apply, please contact
Dir Biological Screening: Matt Jarpe mjarpe@acetylon.com
